Publications - Equipes de l’université de Tours
Secteur Biologie & Santé
UMR INSERM U930 : Imagerie et cerveau
GUERARD S, CHEVALIER Y, MORESCHI H, DEFONTAINE M, CALLE S, MITTON D. Young’s Modulus Repeatability Assessment Using Cyclic Compression Loading on Cancellous Bone. Proc Inst Mech Eng H 2011 ; 225 : 1113-1117.
MORESCHI H, CALLÉ S, GUERARD S, MITTON D, RENAUD G, DEFONTAINE M. Monitoring trabecular bone microdamage using a Dynamic AcoustoElasticTesting Method. Proc Inst Mech Eng H 2011 ; 225 : 282-295.
MORESCHI M, CALLÉ S, GUERARD S, MITTON D, DEFONTAINE M. Detection of micro-damage in the trabecular bone by a method of acousto-elasticity dynamics. IRBM 2011 ; 32 : 269-273.
UMR INSERM U1100 : Centre d'étude des pathologies respiratoires
TOUZÉ A, GAITAN J, ARNOLD F, CAZAL R, FLEURY MJ, COMBELAS N, SIZARET PY, GUYETANT S, MARUANI A, BAAY M, TOGNON M, COURSAGET P. Generation of Merkel cell polyomavirus (MCV)-like particles and their application to detection of MCV antibodies. J Clin Microbiol 2010 ; 48 : 1767-70.
COMBELAS N, SAUSSEREAU E, RIBEIRO T, FLEURY M, GAITAN J, DUARTE D, TOUZÉ A, COURSAGET P. Induction of neutralizing antibodies against heterologous human papillomaviruses (HPV) by immunization with HPV pseudovirions packaged with the L2 gene. J Transl Med 2010 ; 8 : 28.
RIBEIRO T, FLEURY MJ, GRANIERI E, CASTELLAZZI M, MARTINI F, MAZZONI E, COURSAGET P, TOGNON M. Investigation of the prevalence of antibodies against neurotropic polyomaviruses BK, JC and SV40 in sera from patients affected by multiple sclerosis. Neurol Sci 2010 ; 31 : 517-521.
VACCARELLA S, FRANCESCHI S, CLIFFORD GM, TOUZE A, HSU CC, DE SANJOSE S, ANH PTH, HIEU NT, MATOS E, SHIN HR, SUKVIRACH S, THOMAS JO, BOUSARGHIN L, GAITAN J, SNIJDERS PJF, MEIJER CJLM, MUNOZ N, HERRERO R, COURSAGET P. Seroprevalence of antibodies against papillomavirus (HPV) types 16 and 18 in four continents : the IARC HPV Prevalence Surveys. Cancer Epidemiol Biomarkers Prev. 2010 ; 19 : 2379-2388.
TOUZÉ A, LE BIDRE E, LAUDE H, FLEURY MJ, CAZAL R, ARNOLD F, CARLOTTI A, MAUBEC E, AUBIN F, AVRIL MF, ROZENBERG F, TOGNON M, MARUANI A, GUYETANT S, LORETTE G, COURSAGET P. High Levels of Antibodies Against Merkel Cell Polyomavirus Identify a Subset of Patients With Merkel Cell Carcinoma With Better Clinical Outcome. J Clin Oncol. 2011 ; 29 : 1612-1619.
BREA D, MEURENS F, DUBOIS A, GAILLARD J, CHEVALEYRE C, JOURDAN ML, WINTER N, ARBEILLE B, SI-TAHAR M, GAUTHIER F, ATTUCCI S. The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases. Biochem J. 2012 ; 447 : 363-370.
DUBOIS A, GAUTHIER A, BREA D, VARAIGNE F, DIOT P, GAUTHIER F, ATTUCCI S. Influence of DNA on the activities and inhibition of neutrophil serine proteases in cystic fibrosis sputum. Am J Respir Cell Mol Biol. 2012 ; 47 : 80-86.
DESOUBEAUX G, GAILLARD J, BOREE-MOREAU D, BAILLY E, ANDRES CR, CHANDENIER J. Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax. Pathog Glob Health. 2014 ; 108(3) : 158-63.
COMBELAS N, SAUSSEREAU E, RIBEIRO T, FLEURY M, GAITAN J, DUARTE D, TOUZÉ A, COURSAGET P. Induction of neutralizing antibodies against heterologous human papillomaviruses (HPV) by immunization with HPV pseudovirions packaged with the L2 gene. J Transl Med 2010 ; 8 : 28.
RIBEIRO T, FLEURY MJ, GRANIERI E, CASTELLAZZI M, MARTINI F, MAZZONI E, COURSAGET P, TOGNON M. Investigation of the prevalence of antibodies against neurotropic polyomaviruses BK, JC and SV40 in sera from patients affected by multiple sclerosis. Neurol Sci 2010 ; 31 : 517-521.
VACCARELLA S, FRANCESCHI S, CLIFFORD GM, TOUZE A, HSU CC, DE SANJOSE S, ANH PTH, HIEU NT, MATOS E, SHIN HR, SUKVIRACH S, THOMAS JO, BOUSARGHIN L, GAITAN J, SNIJDERS PJF, MEIJER CJLM, MUNOZ N, HERRERO R, COURSAGET P. Seroprevalence of antibodies against papillomavirus (HPV) types 16 and 18 in four continents : the IARC HPV Prevalence Surveys. Cancer Epidemiol Biomarkers Prev. 2010 ; 19 : 2379-2388.
TOUZÉ A, LE BIDRE E, LAUDE H, FLEURY MJ, CAZAL R, ARNOLD F, CARLOTTI A, MAUBEC E, AUBIN F, AVRIL MF, ROZENBERG F, TOGNON M, MARUANI A, GUYETANT S, LORETTE G, COURSAGET P. High Levels of Antibodies Against Merkel Cell Polyomavirus Identify a Subset of Patients With Merkel Cell Carcinoma With Better Clinical Outcome. J Clin Oncol. 2011 ; 29 : 1612-1619.
BREA D, MEURENS F, DUBOIS A, GAILLARD J, CHEVALEYRE C, JOURDAN ML, WINTER N, ARBEILLE B, SI-TAHAR M, GAUTHIER F, ATTUCCI S. The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases. Biochem J. 2012 ; 447 : 363-370.
DUBOIS A, GAUTHIER A, BREA D, VARAIGNE F, DIOT P, GAUTHIER F, ATTUCCI S. Influence of DNA on the activities and inhibition of neutrophil serine proteases in cystic fibrosis sputum. Am J Respir Cell Mol Biol. 2012 ; 47 : 80-86.
DESOUBEAUX G, GAILLARD J, BOREE-MOREAU D, BAILLY E, ANDRES CR, CHANDENIER J. Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax. Pathog Glob Health. 2014 ; 108(3) : 158-63.
UMR INSERM U966 : Morphogénèse et antigénicité du VIH et du virus des hépatites
HAMARD-PERON E, JUILLARD F, SAAD JS, ROY C, ROINGEARD P, SUMMERS MF, DARLIX J-L, PICART C, MURIAUX D. Targeting of MuLV Gag to the plasma membrane is mediated by PI(4,5)P2/PS and a polybasic region in the matrix. J Virol 2010 ; 84 : 503-515.
GOUESLAIN L, ALSALEH K, HORRELOU P, ROINGEARD P, DESCAMPS V, DUVERLIE G, CICZORA Y, WYCHOWSKI C, DUBUISSON J, ROUILLE Y. Identitifation of GBF1 as a cellular factor required for hepatitis C virus RNA replication. J Virol. 2010 ; 84 : 773-787.
DEPLA M, UZBEKOV R, HOURIOUX C, BLANCHARD E, LE GOUGE A, GILLET L, ROINGEARD P. Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein. Cell Mol Life Sci. 2010 ; 67 : 3151-3161
FERRARIS P, BLANCHARD E, ROINGEARD P. Ultrastructural and biochemical analyses of hepatitis c virus associated host cell membranes. J Gen Virol 2010 ; 91 : 2230-2237.
GOUTTENOIRE J, ROINGEARD P, PENIN F, MORADPOUR D. Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B. J Virol 2010 ; 84: 12529-12537
POPESCU I, CALLENS N, TRINEL D, ROINGEARD P, MORADPOUR D, DESCAMPS V, DUVERLIE G, PENIN F, HELIOT L, ROUILLE Y, DUBUISSON J. NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly. PLoS Pathog 2011 ; 7 : e1001278.
RENAULT N, TOBALY-TAPIERO J, PARIS J, GIRON M-L, COIFFIC A, ROINGEARD P, SAIB A. A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication. Retrovirology 2011; 8 : e6.
ROINGEARD P, DEPLA M. The life and birth of lipid droplets : learning from the hepatitis C virus. Biol Cell 2011 ; 103 : 223-231.
OUATTARA LA, BARIN F, BARTHEZ M-A, BONNAUD B, ROINGEARD P, GOUDEAU A, CASTELNAU P, VERNET G, PARANHOS-BACCALA G, KOMURIAN-PRADEL F. Novel human reovirus isolated from children with acute necrotizing encephalopathy, France. Emerg Infect Dis 2011 ; 17 : 1436-1444.
DEPLA M, d’ALTEROCHE L, LE GOUGE A, MOREAU A, HOURIOUX C, MEUNIER JC, GAILLARD J, DE MURET A, BACQ Y, KAZEMI F, AVARGUES A, ROCH E, PIVER E, GAUDY-GRAFFIN C, GIRAUDEAU B, ROINGEARD P. Viral sequence variation in chronic carriers of hepatitis C virus has low impact on liver steatosis. PLoS One. 2012 ; 7 : e33749.
FERRARIS P, BEAUMONT E, UZBEKOV R, BRAND D, GAILLARD J, BLANCHARD E, ROINGEARD P. Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection. Cell Mol Life Sci 2013 ; 70 : 1297-1306.
ROINGEARD P. Hepatitis C virus diversity and liver steatosis. J Viral Hepat 2013 ; 20 : 77-84.
BEAUMONT E, ROINGEARD P. Prospects for prophylactic hepatitis C vaccines based on virus-like particles. Human Vaccin Immunother 2013 ; 9 : 1-7.
UZBEKOV R, ROINGEARD P. Nuclear lipid droplets identified by electron microscopy of serial sections. BMC Res Notes 2013 ; 6 : 386.
GOUESLAIN L, ALSALEH K, HORRELOU P, ROINGEARD P, DESCAMPS V, DUVERLIE G, CICZORA Y, WYCHOWSKI C, DUBUISSON J, ROUILLE Y. Identitifation of GBF1 as a cellular factor required for hepatitis C virus RNA replication. J Virol. 2010 ; 84 : 773-787.
DEPLA M, UZBEKOV R, HOURIOUX C, BLANCHARD E, LE GOUGE A, GILLET L, ROINGEARD P. Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein. Cell Mol Life Sci. 2010 ; 67 : 3151-3161
FERRARIS P, BLANCHARD E, ROINGEARD P. Ultrastructural and biochemical analyses of hepatitis c virus associated host cell membranes. J Gen Virol 2010 ; 91 : 2230-2237.
GOUTTENOIRE J, ROINGEARD P, PENIN F, MORADPOUR D. Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B. J Virol 2010 ; 84: 12529-12537
POPESCU I, CALLENS N, TRINEL D, ROINGEARD P, MORADPOUR D, DESCAMPS V, DUVERLIE G, PENIN F, HELIOT L, ROUILLE Y, DUBUISSON J. NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly. PLoS Pathog 2011 ; 7 : e1001278.
RENAULT N, TOBALY-TAPIERO J, PARIS J, GIRON M-L, COIFFIC A, ROINGEARD P, SAIB A. A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication. Retrovirology 2011; 8 : e6.
ROINGEARD P, DEPLA M. The life and birth of lipid droplets : learning from the hepatitis C virus. Biol Cell 2011 ; 103 : 223-231.
OUATTARA LA, BARIN F, BARTHEZ M-A, BONNAUD B, ROINGEARD P, GOUDEAU A, CASTELNAU P, VERNET G, PARANHOS-BACCALA G, KOMURIAN-PRADEL F. Novel human reovirus isolated from children with acute necrotizing encephalopathy, France. Emerg Infect Dis 2011 ; 17 : 1436-1444.
DEPLA M, d’ALTEROCHE L, LE GOUGE A, MOREAU A, HOURIOUX C, MEUNIER JC, GAILLARD J, DE MURET A, BACQ Y, KAZEMI F, AVARGUES A, ROCH E, PIVER E, GAUDY-GRAFFIN C, GIRAUDEAU B, ROINGEARD P. Viral sequence variation in chronic carriers of hepatitis C virus has low impact on liver steatosis. PLoS One. 2012 ; 7 : e33749.
FERRARIS P, BEAUMONT E, UZBEKOV R, BRAND D, GAILLARD J, BLANCHARD E, ROINGEARD P. Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection. Cell Mol Life Sci 2013 ; 70 : 1297-1306.
ROINGEARD P. Hepatitis C virus diversity and liver steatosis. J Viral Hepat 2013 ; 20 : 77-84.
BEAUMONT E, ROINGEARD P. Prospects for prophylactic hepatitis C vaccines based on virus-like particles. Human Vaccin Immunother 2013 ; 9 : 1-7.
UZBEKOV R, ROINGEARD P. Nuclear lipid droplets identified by electron microscopy of serial sections. BMC Res Notes 2013 ; 6 : 386.
UMR CNRS 7292 : Génétique, immunothérapie, chimie et cancer - GICC
ARNAOTY A, GOUILLEUX-GRUART V, CASTERET S, GOUDEAU E, PITARD P, BIGOT Y, LECOMTE T. Reliability of the nanopheres-DNA immunization technology to produce polyclonal antibodies directed against human neogenic proteins. Mol Genet Genomics 2013 ; 288 : 347-363.
UMR CNRS INRA 7247 : Physiologie de la Reproduction et des Comportements
CHALIVOIX S., MALPAUX B., DUFOURNY L. Relationship between polysialylated neural cell adhesion molecule and β-endorphin- or gonadotropin releasing hormone-containing neurons during activation of the gonadotrope axis in short daylength in the ewe. Neuroscience 2010 ; 169 : 1326-1336.
TILLET Y, TOURLET S, PICARD S, SIZARET PY, CARATY A. Morphofunctional interactions between galanin and GnRH-containing neurones in the diencephalon of the ewe. The effect of oestradiol. J Chem Neuroanat 2012 ; 43 : 14-19.
AUCLAIR S, UZBEKOV R, ELIS S, SANCHEZ L, KIREEV I, LARDIC L, DALBIES-TRAN R, UZBEKOVA S. Absence of cumulus cells during in vitro maturation affects lipid metabolism in bovine oocytes. Am J Physiol Endocrinol Metab 2013 ; 304 : E599-613.
ANGULO L, PERREAU C, LAKHDARI N, UZBEKOV R, PAPILLIER P, FRERET S, CADORET V, GUYADER-JOLY C, ROYERE D, PONSART C, UZBEKOVA S, DALBIES-TRAN R. Breast-cancer anti-estrogen resistance 4 (BCAR4) encodes a novel maternal-effect protein in bovine and is expressed in the oocyte of humans and other non-rodent mammals. Hum Reprod 2013 ; 28: 430-441.
TILLET Y, TOURLET S, PICARD S, SIZARET PY, CARATY A. Morphofunctional interactions between galanin and GnRH-containing neurones in the diencephalon of the ewe. The effect of oestradiol. J Chem Neuroanat 2012 ; 43 : 14-19.
TILLET Y, TOURLET S, PICARD S, SIZARET PY, CARATY A. Morphofunctional interactions between galanin and GnRH-containing neurones in the diencephalon of the ewe. The effect of oestradiol. J Chem Neuroanat 2012 ; 43 : 14-19.
AUCLAIR S, UZBEKOV R, ELIS S, SANCHEZ L, KIREEV I, LARDIC L, DALBIES-TRAN R, UZBEKOVA S. Absence of cumulus cells during in vitro maturation affects lipid metabolism in bovine oocytes. Am J Physiol Endocrinol Metab 2013 ; 304 : E599-613.
ANGULO L, PERREAU C, LAKHDARI N, UZBEKOV R, PAPILLIER P, FRERET S, CADORET V, GUYADER-JOLY C, ROYERE D, PONSART C, UZBEKOVA S, DALBIES-TRAN R. Breast-cancer anti-estrogen resistance 4 (BCAR4) encodes a novel maternal-effect protein in bovine and is expressed in the oocyte of humans and other non-rodent mammals. Hum Reprod 2013 ; 28: 430-441.
TILLET Y, TOURLET S, PICARD S, SIZARET PY, CARATY A. Morphofunctional interactions between galanin and GnRH-containing neurones in the diencephalon of the ewe. The effect of oestradiol. J Chem Neuroanat 2012 ; 43 : 14-19.
UMR INRA 1282 : Infectiologie et Santé Publique
ROSSELIN M, VIRLOGEUX-PAYANT I, ROY C, BOTTREAU E, SIZARET PY, MIJOUIN L, GERMON P, CARON E, VELGE P, WIEDEMANN A. Rck of Salmonella enterica, subspecies enterica serovar Enteritidis, mediates Zipper-like internalization. Cell Res. 2010 ; 20 : 647-664.
RIOU M, GUEGNARD F, SIZARET PY, LE VERN Y, KERBOEUF D. Drug resistance is affected by colocalization of P-glycoproteins in raft-like structures unexpected in eggshells of the nematode Haemonchus contortus. Biochem Cell Biol. 2010 ; 88: 459-467.
ROSSELIN M, ABED N, VIRLOGEUX-PAYANT I, BOTTREAU E, SIZARET PY, VELGE P, WIEDEMANN A. Heterogeneity of type III secretion system (T3SS)-1-independent entry mechanisms used by Salmonella Enteritidis to invade different cell types. Microbiology ; 2011;157 : 839-847.
ZANELLO G, BERRI M, DUPONT J, SIZARET PY, D’INCA R, SALMON H, MEURENS F. Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells. PLoS One ; 2011 ; 6: e18573.
DION S, GERMON S, GUITON R, DUCOURNAU C, DIMIER-POISSON I. Functional activation of T cells by dendritic cells and macrophages exposed to the intracellular parasite Neospora caninum. Int J Parasitol. 2011 ; 41 : 685-695.
NICOL J, TOUZÉ A, ROBINOT R, ARNOLD F, MAZZONI E, TOGNON M, COURSAGET P. Prevalence of serum antibodies to human polyomavirus 9 (HPyV9) and evidence of cross reactivity with the simian lymphotropic polyomavirus (LPyV). Emerg Infect Dis ; 2012 ; 18 : 1329-32.
WIEDEMANN A, ROSSELIN M, MIJOUIN L, BOTTREAU E, VELGE P. Involvement of c-Src tyrosine kinase upstream of class I phosphatidylinositol (PI) 3-kinases in Salmonella Enteritidis Rck protein-mediated invasion. J Biol Chem. 2012 ; 287 : 31148-31154.
MIJOUIN L, ROSSELIN M, BOTTREAU E, PIZARRO-CERDA J, COSSART P, VELGE P, WIEDEMANN A. Salmonella enteritidis Rck-mediated invasion requires activation of Rac1, which is dependent on the class I PI 3-kinases-Akt signaling pathway. FASEB J 2012 ; 26 : 1569-1581.
DENESVRE C. Marek’s disease virus morphogenesis. Avian Dis 2013 ; 57 : 340-350.
RÉMY S, BLONDEAU C, LE VERN Y, LEMESLE M, VAUTHEROT JF, DENESVRE C. Fluorescent tagging of VP22 in N-terminus reveals that VP22 favors Marek’s Disease Virus virulence in chickens and allows morphogenesis study in MD tumor cells. Veterinary Res 2013 (accepté).
RIOU M, GUEGNARD F, SIZARET PY, LE VERN Y, KERBOEUF D. Drug resistance is affected by colocalization of P-glycoproteins in raft-like structures unexpected in eggshells of the nematode Haemonchus contortus. Biochem Cell Biol. 2010 ; 88: 459-467.
ROSSELIN M, ABED N, VIRLOGEUX-PAYANT I, BOTTREAU E, SIZARET PY, VELGE P, WIEDEMANN A. Heterogeneity of type III secretion system (T3SS)-1-independent entry mechanisms used by Salmonella Enteritidis to invade different cell types. Microbiology ; 2011;157 : 839-847.
ZANELLO G, BERRI M, DUPONT J, SIZARET PY, D’INCA R, SALMON H, MEURENS F. Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells. PLoS One ; 2011 ; 6: e18573.
DION S, GERMON S, GUITON R, DUCOURNAU C, DIMIER-POISSON I. Functional activation of T cells by dendritic cells and macrophages exposed to the intracellular parasite Neospora caninum. Int J Parasitol. 2011 ; 41 : 685-695.
NICOL J, TOUZÉ A, ROBINOT R, ARNOLD F, MAZZONI E, TOGNON M, COURSAGET P. Prevalence of serum antibodies to human polyomavirus 9 (HPyV9) and evidence of cross reactivity with the simian lymphotropic polyomavirus (LPyV). Emerg Infect Dis ; 2012 ; 18 : 1329-32.
WIEDEMANN A, ROSSELIN M, MIJOUIN L, BOTTREAU E, VELGE P. Involvement of c-Src tyrosine kinase upstream of class I phosphatidylinositol (PI) 3-kinases in Salmonella Enteritidis Rck protein-mediated invasion. J Biol Chem. 2012 ; 287 : 31148-31154.
MIJOUIN L, ROSSELIN M, BOTTREAU E, PIZARRO-CERDA J, COSSART P, VELGE P, WIEDEMANN A. Salmonella enteritidis Rck-mediated invasion requires activation of Rac1, which is dependent on the class I PI 3-kinases-Akt signaling pathway. FASEB J 2012 ; 26 : 1569-1581.
DENESVRE C. Marek’s disease virus morphogenesis. Avian Dis 2013 ; 57 : 340-350.
RÉMY S, BLONDEAU C, LE VERN Y, LEMESLE M, VAUTHEROT JF, DENESVRE C. Fluorescent tagging of VP22 in N-terminus reveals that VP22 favors Marek’s Disease Virus virulence in chickens and allows morphogenesis study in MD tumor cells. Veterinary Res 2013 (accepté).
EA 6295 : Nanomédicaments et nanosondes
KAAKI K, HERVÉ-AUBERT K, CHIPER M, SHKILNYY A, SOUCÉ M, BENOIT R, PAILLARD A, DUBOIS P, SABOUNGI ML, CHOURPA I. Magnetic nanocarriers of doxorubicin coated with poly (ethylene glycol) and folic acid: relation between coating structure, surface properties, colloidal stability, and cancer cell targeting. Langmuir 2012 ; 28 : 1496-505.
EA 3852 : Laboratoire de Physiopathologie de la Paroi Artérielle
HYVELIN JM, MAUREL B, UZBEKOV R, MOTTERLINI R, LERMUSIAUX P. Hemin prevents in-stent stenosis in rat and rabbit models by inducing heme-oxygenase-1. J Vasc Surg 2010 ; 51 : 417-28.